2-(asetamidometilen)suksinat gidrolaza

Enzimologiyada 2-(asetamidometilen)suksinat gidrolaza (EC)) kimyoviy reaksiyani katalizlovchi ferment hisoblanadi.

2-(asetamidometilen)suksinat + 2 H ₂ O $\rightleftharpoons$ asetat + suksinat yarimaldegid + NH ₃ + CO ₂

Shunday qilib, ushbu fermentning ikkita substrati 2-(asetamidometilen)süksinat va H ₂ O, uning 4 ta mahsuloti asetat, suksinat yarimaldegid, NH ₃ va CO ₂ dir.

Bu ferment peptid aloqalaridan tashqari uglerod-azot aloqalarida, xususan, chiziqli amidlarda taʼsir qiluvchi gidrolazalar oilasiga tegishli boʻlib, ushbu ferment sinfining tizimli nomi 2-(asetamidometilen)suksinat amidohidrolaza (deaminatsiya qiluvchi, dekarboksillovchi) hisoblanadi. Bu ferment alfa-(N-asetilaminometilen)suksinik kislota gidrolaza deb ham ataladi. Bu ferment B6 _vitamini metabolizmida ishtirok etadi.

Manbalar

• "Enzymes of vitamin B₆ degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260 (4): 2379–83. 1985. PMID 3972793. https://archive.org/details/sim_journal-of-biological-chemistry_1985-02-25_260_4/page/2378. 
• "The bacterial oxidation of vitamin B₆. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid". J. Biol. Chem. 244 (10): 2601–5. 1969. PMID 5769993. https://archive.org/details/sim_journal-of-biological-chemistry_1969-05-25_244_10/page/n110.